Rub entire surface of beef roast with Cajun seasoning. In 3- to 3 1/2-quart slow cooker, place roast. Top with frozen corn, onion and bell pepper.
In small bowl, mix tomatoes, pepper and pepper sauce. Pour over vegetables and roast.
Cover; cook on Low heat setting 7 to 8 hours.
To serve, cut roast into slices. Using a slotted spoon, remove corn mixture and serve with roast.