Heat oven to 400°F. Spray cookie sheet with cooking spray or grease with shortening. Unroll dough onto cookie sheet. Starting at center, press out dough into 14x8-inch rectangle.
Spread honey-mustard over dough to within 1 inch of edges. Layer ham and cheese over mustard.
Fold long sides of dough over filling to center of rectangle; pinch to seal. Pinch short sides to seal and tuck under. Brush with egg; sprinkle with sesame seed.
Bake 16 to 18 minutes or until crust is golden brown. Cut into 6 pieces; serve warm.