Heat oven to 350°F. In large bowl, combine all meat loaf ingredients; mix well. Press mixture in ungreased 8x4-inch loaf pan. Bake at 350°F. for 40 minutes.
Remove meat loaf from oven. Spread 1/4 cup ketchup evenly over top. Return to oven; bake an additional 15 to 20 minutes or until meat thermometer reaches 160°F. and beef is thoroughly cooked. Let stand 10 minutes before serving.