Cook fettuccine to desired doneness as directed on package. Drain; cover to keep warm.
Meanwhile, brown ground beef in large skillet over medium-high heat until thoroughly cooked, stirring frequently. Drain.
Add bell peppers; cook and stir 4 to 6 minutes or until peppers are crisp-tender.
Add half-and-half, pesto, salt, pepper and cooked fettuccine. Reduce heat to medium; cook and stir 3 to 5 minutes or until thoroughly heated, stirring occasionally.