Heat gas or charcoal grill. In large bowl, mix ground beef, Worcestershire sauce, seasoned salt, onion powder and pepper until well blended. Shape mixture into 8 patties, about 3/4 inch thick.
Place patties on grill. Cover grill; cook over medium heat 13 to 15 minutes, turning once, until meat thermometer inserted in center of patties reads 160°F.
Layer buns with lettuce, tomato slices and burger patties. If desired, serve with ketchup, mustard, pickles and onions.