Heat oven to 375°F. Spray 2-quart baking dish with cooking spray.
Cook and drain pasta as directed on package using minimum cook time. In large bowl, stir Alfredo sauce, wine, Italian seasoning, lemon peel, tuna, peas, mushrooms and pasta. Spoon into baking dish.
In small bowl, stir together bread crumbs and butter; sprinkle in baking dish.
Bake 25 to 30 minutes or until topping is golden brown.