Rub entire surface of beef roast with Cajun seasoning. In 3 1/2- to 4-quart slow cooker, place roast. Top with frozen corn, onion and bell pepper.
In small bowl, mix tomatoes, pepper and pepper sauce. Pour over vegetables and roast.
Cover; cook on Low heat setting 8 to 10 hours.
To serve, cut roast into slices. Using a slotted spoon, remove corn mixture and serve with roast.